What is Fisetin?

A Natural Approach to Wellness.


So what is Fisetin?

Fisetin, a potent flavonoid, is a natural constituent present in a variety of fruits and vegetables, with levels ranging from 2 to 160 micrograms per gram of the respective produce. It falls under the category of flavonoids, a group of compounds recognized for their numerous health advantages.



what can Fisetin do for you?

Antioxidant properties

Fisetin is known for its antioxidant activity, which means it can help combat oxidative stress in the body.

 Oxidative stress is linked to various chronic diseases and aging processes, so antioxidants like fisetin can help protect cells from damage caused by free radicals.

Anti-inflammatory properties

Fisetin has shown anti-inflammatory properties in several studies.

 Chronic inflammation is associated with various health issues, including cardiovascular diseases, neurodegenerative disorders, and cancer. Fisetin’s anti-inflammatory effects may contribute to overall health and disease prevention.


Some studies suggest that Fisetin might have neuroprotective effects.

It has been investigated for its potential to protect neurons from damage, reduce inflammation in the brain, and potentially mitigate the risk of neurodegenerative disorders like Alzheimer’s and Parkinson’s diseases.

Cognitive Function

Fisetin has been explored for its potential to support cognitive function and memory.

Fisetin has been explored for its potential to support cognitive function and memory.

Anti-Cancer Properties

Preliminary research suggests that Fisetin may have anti-cancer properties.

It has been studied for its potential to inhibit the growth of cancer cells, induce apoptosis (programmed cell death) in cancer cells, and interfere with processes that promote cancer development.

Fisetin vs Quercetin

In addition to fisetin, another compound known for its senolytic properties is quercetin. Although quercetin and fisetin share structural similarities, fisetin stands out as a more effective and safer natural senolytic agent.

Fisetin has demonstrated a greater efficacy in eliminating senescent cells (indicated by the red bar) compared to other compounds like quercetin, curcumin, and EGCG, as indicated in the source image from the study titled “Fisetin is a senotherapeutic that extends health and lifespan” published in EBioMedicine in 2018. This suggests that fisetin holds significant potential as a senolytic agent for promoting health and extending lifespan.

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Frequently Asked Questions

Most frequent questions and answers

Fisetin has the potential to offer considerable health advantages without notable side effects. Its affordability also makes it a convenient supplement option. If scientific research can confirm fisetin’s benefits through human trials, using it as a supplement could be a logical step. Nevertheless, consulting a healthcare professional before beginning any new supplement is crucial to ensure safety.

Numerous animal experiments have demonstrated promising outcomes suggesting that fisetin could potentially offer anti-aging effects, leading to increased lifespan. However, the absence of clinical trials involving humans using fisetin supplements leaves this possibility uncertain. In order to bridge this knowledge gap, various organizations and universities are currently conducting clinical studies on human subjects. The aim is to determine whether the positive results observed in animal studies can be replicated in humans through the supplementation of fisetin.

Yes, fisetin has the ability to enhance the generation of glutathione, which is a natural antioxidant produced within the body. This action leads to a heightened level of antioxidant effectiveness attributed to fisetin. The augmentation in glutathione is considered a crucial mechanism by which fisetin contributes to shielding the brain from potential harm after a stroke occurs.

Fisetin is a natural compound present in numerous fruits and vegetables, with strawberries being the richest source. Among various foods, strawberries contain the most substantial quantity of fisetin, measuring about 160 micrograms per gram of strawberry. Even though this quantity is notably lower than what’s commonly found in supplements, it remains the highest concentration discovered in any food item.

Numerous research experiments have been carried out using animal subjects, demonstrating that fisetin possesses senolytic properties. These studies have indicated that fisetin administration can extend the lifespan of mice. However, the investigation into these impacts in human subjects remains limited and relatively scarce.

At present, there have been no documented adverse effects linked to fisetin consumption. Nonetheless, the scope of clinical trials involving humans remains restricted, and the potential outcomes of using fisetin supplements over extended periods are yet to be ascertained. Augmenting your fisetin intake through the inclusion of more fruits and vegetables containing this compound in your diet is considered entirely safe.

Even though no unfavorable effects are currently recognized, it’s prudent to engage in a conversation with your doctor or pharmacist before initiating any new supplementation. This precaution ensures both safety and the absence of interactions with any ongoing medication regimens.

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