Skin elasticity naturally changes with age as collagen and elastin undergo structural changes. But what actually causes skin to lose its firmness and ability to bounce back? Explore the science...
NAD+ plays an essential role in cellular energy, DNA repair and metabolism, but does increasing it actually slow aging? Explore how NMN supports NAD+ production, what human clinical trials have...
A randomized human trial found promising changes in glutathione, oxidative stress, mitochondrial function and physical performance after GlyNAC supplementation. But only 24 older adults were randomized. Explore the study design,...
Urolithin A is gaining attention for its potential role in muscle health and mitochondrial function. But what do human clinical trials actually show? Explore the evidence on muscle endurance, strength,...
The claim that PABA can restore gray hair traces back to research conducted decades ago, including a frequently cited report involving 460 people. Explore what researchers actually observed, the doses...
NAD+ is essential for cellular metabolism, and NMN is one of the molecules the body can use to make it. Explore why researchers study NMN, what human trials actually measure,...
You've Probably Seen the NAD+ Aging Graph It usually looks something like this: Young age → High NAD+ ↓ Middle age → Lower NAD+ ↓ Older age → Very low...
Fisetin is often called a senolytic, but what would actually prove that it clears senescent cells in humans? Explore the difference between cell studies, animal experiments, human biomarkers, tissue-level evidence...
A randomized GlyNAC trial reported improvements in glutathione, oxidative stress, mitochondrial function, inflammation and physical function in older adults but only 12 participants received GlyNAC. Here’s what the study actually...
Aging isn't driven by one biological pathway. From DNA damage and epigenetic changes to mitochondrial dysfunction, cellular senescence, inflammation and the microbiome, discover the 12 Hallmarks of Aging and the...
Scientists can reprogram adult human skin cells into an embryonic-like pluripotent state and researchers have even done it by activating the cells' own genes with CRISPRa. Here's what cellular reprogramming...
Urolithin A is being studied for its connection to mitochondria, mitophagy and muscle function but human trials tell a more nuanced story. Discover how gut bacteria produce Urolithin A, what...
Could four weeks of diet change signals linked to inflammation and biological aging? A 2026 randomized study analyzed more than 800,000 DNA methylation sites after vegan and meat-rich diets. Here’s...