What Is Fisetin?
In Aeternum Podcast Episode 8, we dive into fisetin, a natural flavonoid found in fruits and vegetables like strawberries, apples, grapes, and onions. Scientists are increasingly interested in fisetin for its senolytic properties — meaning it may help the body clear out dysfunctional “zombie” cells that accumulate with age and drive chronic inflammation and tissue dysfunction. lifeextension.com+1
How Fisetin Works, Senolytic & Anti-Aging Actions
Research shows that fisetin can selectively target and remove senescent cells — old, damaged cells that resist natural cell death and contribute to aging and age-related diseases. Removing these cells may improve tissue function and support healthspan and lifespan. PubMed
In animal studies, old mice given fisetin showed improved tissue health and extended median and maximum lifespan, even when the compound was administered later in life. PubMed
Science-Backed Benefits of Fisetin
Here are some promising ways fisetin may support health and aging:
1. Senolytic Action & Longevity
Fisetin stands out as one of the most potent natural senolytic compounds, helping clear senescent cells and reduce age-related pathology in multiple tissues. PubMed
2. Reduced Inflammation and Oxidative Stress
Fisetin has strong antioxidant and anti-inflammatory effects, helping calm chronic inflammation — a key driver of aging and disease — and scavenging damaging free radicals. lifeextension.com+1
3. Metabolic & Cellular Support
Studies suggest fisetin may help activate beneficial cellular pathways like AMPK and inhibit harmful ones like mTOR, supporting healthy metabolism and cellular “housekeeping” (autophagy), which helps rejuvenate cells. lifeextension.com
4. Brain & Heart Function
Animal research indicates fisetin may protect brain cells against oxidative damage and support endothelial (cardiovascular) health, helping maintain function with age. Landys Chemist
Practical Insights from Episode 8
✔ Fisetin is a natural compound found in foods such as strawberries and apples. lifeextension.com
✔ It may help remove senescent cells and support healthy aging. PubMed
✔ Most research is preclinical, meaning human results are still emerging. Acta Scientific
✔ Combining fisetin with other lifestyle strategies may offer greater effects.